indianz.com your internet resource indianz.com on facebook indianz.com on twitter indianz.com on Google+
ph: 202 630 8439
Kill The Tobacco Master Settlement Agreement
Advertise on Indianz.Com
Home > News > Headlines
Print   Subscribe
Opinion: DNA tests offer clues into Indian and Spanish ancestry

Filed Under: Health | Opinion | World
More on: cancer, colombia, dna
   

Cancer researchers are finding clues about the mixed Indian and Spanish origins of remote villages in the Andes of Columbia:
With support from UC Davis, GSK Oncology, and V Foundation grants, we are working to identify new genes associated with breast cancer. Plans are in place to validate relevancy of the discoveries through partnerships with other investigators at UC Davis, Stanford, UCSF, University of Southern California, and the Cancer Prevention Institute of California. Our work has already revealed interesting background on the history and ancestry of these villagers.

Studies of maternal lines through mitochondrial DNA as it is passed from mothers to children have shown that ancestral mothers were primarily Native American. More surprising is the paternal lineage. Our testing in men found that almost all the genetic makeup of the Y chromosome DNA is European in origin.

It is likely that male Spanish conquistadors settled in the area, taking Native American women as wives. The male Native American population was presumably decimated from disease and conflict. Few European women came to the area, so the European men married the remaining Native American women, each passing on their genetic lines. These findings are among the most striking examples of male-driven directional mating in humans and have been subsequently replicated by many researchers in other Hispanic populations.

The homogeneity of these Andean villagers means there are large families with the same cancers caused by very few mutations passed down by village ancestors. We have screened 191 women with breast cancer in Colombia and identified 25 patients and families with the same genetic mutation in the BRCA1 gene. Genealogical studies indicate the mutation was likely introduced by a Spanish ancestor who settled in the Huila Province and whose descendants still live in the region. We are now using modern genome sequencing methods to identify mutations in new genes as we expect that many more “founder mutations” are still undiscovered and will give us clues about genetic susceptibility to cancer and its biology.

Get the Story:
Luis Carvajal-Carmona: Genetic Analysis of Remote Population May Advance Breast Cancer Prevention and Treatment (OncLive 2/18)


Copyright © Indianz.Com
More headlines...
Stay Connected:

Local Links:
Federal Register | Indian Gaming | Jobs & Notices | In The Hoop | Message Board
Latest News:
Native Sun News: Tribe threw away late veteran's memorabilia (10/31)
Mark Trahant: The Native vote could decide the 2014 election (10/31)
Richard Peterson: Sen. Begich supports Alaska Native issues (10/31)
NCAI investigates conduct of treasurer at annual convention (10/31)
Red Lake News: Tribe welcomes Sen. Tester and Sen. Franken (10/31)
Former chairman of Chippewa Cree Tribe faces more charges (10/31)
Texas couple accused of selling fake tribal membership cards (10/31)
Moapa Band loses bid for $438M solar facility on reservation (10/31)
Passamaquoddy Tribe won't talk with tidal power developers (10/31)
Oregon tribe anticipates May 2015 opening for Class II casino (10/31)
Trial opens in case connected to Choctaw Nation casino work (10/31)
Editorial: Off-reservation gaming project unfair to other tribes (10/31)
Opinion: Menominee Nation exploits loophole to pursue casino (10/31)
Native Sun News: Oglala Sioux officer rejoins Rapid City police (10/30)
Mark Trahant: Native voters must be prepared on election day (10/30)
Kevin Gover: Mascot fight exposes myths about Native people (10/30)
Northern Arapaho Tribe: Newspaper got it wrong on joint council (10/30)
Peter d'Errico: Kevin Washburn honored by Indian law students (10/30)
Chris Deschene still urging Navajo Nation voters to choose him (10/30)
Tribes in North Carolina back Democrat Sen. Hagan in tight race (10/30)
NWPR: Tribes take steps to control growing herds of wild horses (10/30)
Opinion: Helping the Tongva people revive their own language (10/30)
Judge grants injunction to keep Chukchansi Tribe casino closed (10/30)
Tribes in South Dakota would benefit from gaming referendum (10/30)
Employee at Puyallup Tribe's casino gets wedding ring returned (10/30)
Editorial: Keep tribal casinos in California on existing Indian land (10/30)
Column: Menominee Nation off-reservation casino goes ignored (10/30)
Quapaw Tribe faces competition for Kansas commercial casino (10/30)
Native Sun News: Montana tribe sees cut in heating assistance (10/29)
Mark Trahant: Alaska Senate race is a real test of Native policy (10/29)
Winona LaDuke: Taking treaty advice from indigenous nations (10/29)
Vena A-Dae Romero: FDA failing to consult tribal governments (10/29)
Zachary Pullin: Native Americans overcame barriers to voting (10/29)
Navajo Nation president vetoes bill to address language issue (10/29)
Prairie Island Indian Community sues over nuclear waste rule (10/29)
County's letter on CSKT water compact talks stirs controversy (10/29)
Vice: Hip-hop artist Drezus on new journey after jail sentence (10/29)
Opinion: Overcoming stereotypes of Native American culture (10/29)
Charges sought in dispute at Chukchansi Tribe's closed casino (10/29)
Pechanga Band chair featured in ads against North Fork casino (10/29)
Grand Ronde Tribes continue fight against Cowlitz Tribe casino (10/29)
Puyallup Tribe offers reward for return of casino worker's ring (10/29)
more headlines...

Home | Arts & Entertainment | Business | Canada | Cobell Lawsuit | Education | Environment | Federal Recognition | Federal Register | Forum | Health | Humor | Indian Gaming | Indian Trust | Jack Abramoff Scandal | Jobs & Notices | Law | National | News | Opinion | Politics | Sports | Technology | World

Indianz.Com Terms of Service | Indianz.Com Privacy Policy
About Indianz.Com | Advertise on Indianz.Com

Indianz.Com is a product of Noble Savage Media, LLC and Ho-Chunk, Inc.