indianz.com your internet resource indianz.com on facebook indianz.com on twitter indianz.com on Google+ indianz.com on soundcloud
phone: 202 630 8439
The Rise of Tribes and the Fall of Federal Indian Law
Advertise on Indianz.Com
Home > News > Headlines
Print   Subscribe
Opinion: DNA tests offer clues into Indian and Spanish ancestry

Filed Under: Health | Opinion | World
More on: cancer, colombia, dna
     

Cancer researchers are finding clues about the mixed Indian and Spanish origins of remote villages in the Andes of Columbia:
With support from UC Davis, GSK Oncology, and V Foundation grants, we are working to identify new genes associated with breast cancer. Plans are in place to validate relevancy of the discoveries through partnerships with other investigators at UC Davis, Stanford, UCSF, University of Southern California, and the Cancer Prevention Institute of California. Our work has already revealed interesting background on the history and ancestry of these villagers.

Studies of maternal lines through mitochondrial DNA as it is passed from mothers to children have shown that ancestral mothers were primarily Native American. More surprising is the paternal lineage. Our testing in men found that almost all the genetic makeup of the Y chromosome DNA is European in origin.

It is likely that male Spanish conquistadors settled in the area, taking Native American women as wives. The male Native American population was presumably decimated from disease and conflict. Few European women came to the area, so the European men married the remaining Native American women, each passing on their genetic lines. These findings are among the most striking examples of male-driven directional mating in humans and have been subsequently replicated by many researchers in other Hispanic populations.

The homogeneity of these Andean villagers means there are large families with the same cancers caused by very few mutations passed down by village ancestors. We have screened 191 women with breast cancer in Colombia and identified 25 patients and families with the same genetic mutation in the BRCA1 gene. Genealogical studies indicate the mutation was likely introduced by a Spanish ancestor who settled in the Huila Province and whose descendants still live in the region. We are now using modern genome sequencing methods to identify mutations in new genes as we expect that many more “founder mutations” are still undiscovered and will give us clues about genetic susceptibility to cancer and its biology.

Get the Story:
Luis Carvajal-Carmona: Genetic Analysis of Remote Population May Advance Breast Cancer Prevention and Treatment (OncLive 2/18)


Copyright © Indianz.Com
More headlines...
Stay Connected:
On Facebook

On Twitter

On Google+

On SoundCloud
Local Links:
Federal Register | Indian Gaming | Jobs & Notices | In The Hoop | Message Board
Latest News:
Field hearing in South Dakota on Indian Health Service reform bill (5/31)
Supreme Court won't hear long-running Seneca Nation casino case (5/31)
Native Sun News: Longtime Indian Health Service staff reassigned (5/31)
Lakota Country Times: Native newspaper brings home 14 awards (5/31)
Delphine Red Shirt: Our language doesn't need 'expert' approval (5/31)
Clara Caufield: Northern Cheyenne show love for commod cheese (5/31)
Editorial: Newspaper continues to grow and reach Native readers (5/31)
Mary Annette Pember: Rosebud Sioux Tribe battles meth epidemic (5/31)
Ruth Hopkins: Elizabeth Warren is counting coup on Donald Trump (5/31)
Debra Haaland: Donald Trump mocks Native people and our history (5/31)
Harlan McKosato: Let's conduct new poll on the racist NFL mascot (5/31)
Raymond Foxworth: Tribal opposition to racist names still matters (5/31)
Steven Newcomb: Original nations pushed to accept lower status (5/31)
Mike Myers: Roadblocks to true self-governance in Indian Country (5/31)
Carly McIntosh: A real live study on the use of medical marijuana (5/31)
First Lady Michelle Obama shares story of hope with Indian school (5/26)
Remarks by First Lady Michelle Obama at Santa Fe Indian School (5/26)
Gary Davis of NCAIED joins Small Business Administration council (5/26)
Arne Vainio: A mother's gift carried me through many life journeys (5/26)
Native Sun News: Tribes score big in fights against energy projects (5/26)
Lakota Country Times: Education Secretary hears from Pine Ridge (5/26)
Ivan Star Comes Out: Ending Whiteclay beer sales starts at home (5/26)
Vi Waln: Rosebud Sioux youth lead efforts to bring relatives home (5/26)
Gyasi Ross: Drug epidemic sweeping through Native communities (5/26)
Jacqueline Keeler: Shameful and skewed poll on racist NFL name (5/26)
Interview with Melvin Monette about Cobell scholarship program (5/26)
Auction house in France won't stop sale of sacred tribal property (5/26)
United Keetoowah Band installs new leader after impeachment (5/26)
Kewa Pueblo builds new community around historic trading post (5/26)
Eastern Cherokee elder translates 'Charlotte's Web' into Tsalagi (5/26)
Puyallup Tribe works to keep language alive for new generations (5/26)
Iowa Tribe offers free play on poker website ahead of full launch (5/26)
Alabama-Coushatta Tribe offers gaming options closer to home (5/26)
Kaw Nation receives national award for tribal gaming initiatives (5/26)
Indian Health Service reform efforts gaining steam on Capitol Hill (5/25)
Indian Health Service announces more hires at troubled hospital (5/25)
Keepseagle attorneys open application process for $38M in grants (5/25)
Three tribes enter cooperative agreements for buy-back program (5/25)
New leader selected for HUD's Office of Native American Programs (5/25)
Indian relay racers gear up for event hosted by Muckleshoot Tribe (5/25)
Cronkite News: Tribes seek return of property up for sale in France (5/25)
Native Sun News: Anti-suicide effort incorporates tribal traditions (5/25)
Lakota Country Times: Pine Ridge youth showcase film projects (5/25)
Mark Trahant: Native vote victory for Tawna Sanchez in Oregon (5/25)
Brandon Ecoffey: Lakota people come together in times of need (5/25)
Editorial: Tribes must come up with plan for return of Black Hills (5/25)
John McCoy: Disenrollment and blood quantum are not our way (5/25)
Adrian Jawort: Addressing race relations and healing in Montana (5/25)
Fort Peck Tribes oppose new directive on transgender students (5/25)
Leader of United Keetoowah Band ousted through impeachment (5/25)
more headlines...

Home | Arts & Entertainment | Business | Canada | Cobell Lawsuit | Education | Environment | Federal Recognition | Federal Register | Forum | Health | Humor | Indian Gaming | Indian Trust | Jack Abramoff Scandal | Jobs & Notices | Law | National | News | Opinion | Politics | Sports | Technology | World

Indianz.Com Terms of Service | Indianz.Com Privacy Policy
About Indianz.Com | Advertise on Indianz.Com

Indianz.Com is a product of Noble Savage Media, LLC and Ho-Chunk, Inc.